Relative contraindications

  • Severe pulmonary HTN where blockade of lung capillaries may acutely exacerbate the condition
  • Right-to-left shunts, take care with these, but advers effects on coronary or cerebral circulations have rarely been observed
    • Can easily detect by immediate presence of renal activity best seen on posterior to lateral views and can be confirmed by demonstration of activity in the brain

MAA injection

  • Shouldn’t be injected through a filtered needle or a Swan
  • If drawing blood into syringe to confirm needle location, should not delay injecting or clots can form and will have clinically insignificant but radiolabeled clots

Modified PIOPED II

High

≥2 large mismatched V/Q segmental defects

Nondiagnostic

All other findings

Very Low

  • Nonsegmental
  • Q defect < CXR lesion
    • If perfusion defect is substantially smaller than the corresponding radiographic abnormality, the probability of PE is very low (an infarction logically shouldn’t be bigger than the perfusion defect)
  • Solitary matched V/Q/CXR defect (≤1 segment) in mid or upper lung
    • AKA “triple match”
    • Evidence that triple match lower lobe, where blood flow is greater, more commonly represents PE thus making a lower lobe triple match intermediate probability
  • 1-3 small segmental defects
  • Matched V/Q defects in ≥2 zones of one lung, regionally normal CXR
  • Stripe sign
  • Solitary large pleural effusion
  • Normal
  • No perfusion defects

Ancillary signs

Stripe sign

  • Thin line/stripe of activity representing perfused lung tissue between a perfusion defect and adjacent pleural surface
  • With emboli, perfusion defect should go all the way to pleura
  • Most commonly due to emphysema

Special situations

  • Lobar or whole-lung defects are unusual presentations for PE
    • Consider hilar masses, mediastinal fibrosis, and hypoplastic pulmonary artery
  • Severe, diffuse COPD may lead to nondiagnostic V/Q
  • Triple matches in upper or mid zones are very low probability while lower zones is intermediate probability