Relative contraindications
- Severe pulmonary HTN where blockade of lung capillaries may acutely exacerbate the condition
- Right-to-left shunts, take care with these, but advers effects on coronary or cerebral circulations have rarely been observed
- Can easily detect by immediate presence of renal activity best seen on posterior to lateral views and can be confirmed by demonstration of activity in the brain

- Can easily detect by immediate presence of renal activity best seen on posterior to lateral views and can be confirmed by demonstration of activity in the brain
MAA injection
- Shouldn’t be injected through a filtered needle or a Swan
- If drawing blood into syringe to confirm needle location, should not delay injecting or clots can form and will have clinically insignificant but radiolabeled clots
Modified PIOPED II
High
≥2 large mismatched V/Q segmental defects
Nondiagnostic
All other findings
Very Low
- Nonsegmental
- Q defect < CXR lesion
- If perfusion defect is substantially smaller than the corresponding radiographic abnormality, the probability of PE is very low (an infarction logically shouldn’t be bigger than the perfusion defect)
- Solitary matched V/Q/CXR defect (≤1 segment) in mid or upper lung
- AKA “triple match”
- Evidence that triple match lower lobe, where blood flow is greater, more commonly represents PE thus making a lower lobe triple match intermediate probability
- 1-3 small segmental defects
- Matched V/Q defects in ≥2 zones of one lung, regionally normal CXR
- Stripe sign
- Solitary large pleural effusion
- Normal
- No perfusion defects
Ancillary signs
Stripe sign
- Thin line/stripe of activity representing perfused lung tissue between a perfusion defect and adjacent pleural surface
- With emboli, perfusion defect should go all the way to pleura
- Most commonly due to emphysema

Special situations
- Lobar or whole-lung defects are unusual presentations for PE
- Consider hilar masses, mediastinal fibrosis, and hypoplastic pulmonary artery
- Severe, diffuse COPD may lead to nondiagnostic V/Q
- Triple matches in upper or mid zones are very low probability while lower zones is intermediate probability
